by Christine March, Jazan Omari, Alexey Surov, Maximilian Thormann, Peter Hass, Maciej Pech, Robert Damm
Abstract:
PURPOSE: Image-guided brachytherapy with a single-fraction irradiation (high-dose-rate brachytherapy - HDR-BT) is a promising local ablation technique for unresectable liver metastases. The occurrence of needle track seeding after biopsy and microwave ablation (MWA) has been documented primarily in hepatocellular carcinoma (HCC). Comprehensive data on colorectal metastases and treatment with HDR-BT is missing. The aim of this study was to investigate the incidence of extra- and intra-hepatic track seeding after HDR-BT in patients with colorectal metastases of the liver, and the identification of possible risk factors. MATERIAL AND METHODS: Patients with at least one treatment of HDR-BT were included. Two readers identified possible track seeding after at least 3 months of follow-up. For verification, we used image fusion of CT/MRI images from 3D irradiation plan and follow-up. Intra- and extra-hepatic seeding were included. As possible risk factors, demographics, tumor grading, and aspects of catheter placement were identified, and generalized linear mixed model for evaluation was applied. RESULTS: On total, 138 patients were included in the study (85 males). We treated 472 liver lesions with 1,107 catheter placements. Sixteen needle track lesions were identified with a catheter-based risk of 1.5\% and patient-based risk of 10.9\% during a median follow-up of 543 days. Extra-hepatic track seeding (patient-based risk of 1.4\%) was found in two patients only. Possible risk factors were tumor grading (p = 0.01) and using
Reference:
Needle track seeding in colorectal carcinoma after local ablation by high-dose-rate brachytherapy: a retrospective study of 1,107 catheter placements. (Christine March, Jazan Omari, Alexey Surov, Maximilian Thormann, Peter Hass, Maciej Pech, Robert Damm), In Journal of contemporary brachytherapy, volume 14, 2022.
Bibtex Entry:
@article{march_needle_2022,
	title = {Needle track seeding in colorectal carcinoma after local ablation by  high-dose-rate brachytherapy: a retrospective study of 1,107 catheter placements.},
	volume = {14},
	copyright = {Copyright © 2022 Termedia.},
	issn = {1689-832X 2081-2841 2081-2841},
	doi = {10.5114/jcb.2022.115377},
	abstract = {PURPOSE: Image-guided brachytherapy with a single-fraction irradiation  (high-dose-rate brachytherapy - HDR-BT) is a promising local ablation technique  for unresectable liver metastases. The occurrence of needle track seeding after  biopsy and microwave ablation (MWA) has been documented primarily in  hepatocellular carcinoma (HCC). Comprehensive data on colorectal metastases and  treatment with HDR-BT is missing. The aim of this study was to investigate the  incidence of extra- and intra-hepatic track seeding after HDR-BT in patients with  colorectal metastases of the liver, and the identification of possible risk  factors. MATERIAL AND METHODS: Patients with at least one treatment of HDR-BT  were included. Two readers identified possible track seeding after at least 3  months of follow-up. For verification, we used image fusion of CT/MRI images from  3D irradiation plan and follow-up. Intra- and extra-hepatic seeding were  included. As possible risk factors, demographics, tumor grading, and aspects of  catheter placement were identified, and generalized linear mixed model for  evaluation was applied. RESULTS: On total, 138 patients were included in the  study (85 males). We treated 472 liver lesions with 1,107 catheter placements.  Sixteen needle track lesions were identified with a catheter-based risk of 1.5\%  and patient-based risk of 10.9\% during a median follow-up of 543 days.  Extra-hepatic track seeding (patient-based risk of 1.4\%) was found in two  patients only. Possible risk factors were tumor grading (p = 0.01) and using},
	language = {eng},
	number = {2},
	journal = {Journal of contemporary brachytherapy},
	author = {March, Christine and Omari, Jazan and Surov, Alexey and Thormann, Maximilian and Hass, Peter and Pech, Maciej and Damm, Robert},
	month = apr,
	year = {2022},
	pmid = {35494186},
	pmcid = {PMC9044299},
	keywords = {after-loading, colorectal metastases, track ablation},
	pages = {169--175}
}