Two-dimensional parametric parenchymal blood flow in transarterial chemoembolisation for hepatocellular carcinoma: perfusion change quantification and tumour response prediction at 3 months post-intervention.

Becker, Lena S.; Maschke, Sabine K.; Dewald, C. L. A.; Meine, T. C.; Winther, Hinrich B. M.; Kirstein, M. M.; Kloeckner, Roman; Meyer, Bernhard Christian; Wacker, Frank K.; Hinrichs, Jan B.

doi:10.1016/j.crad.2020.09.012

by Lena S. Becker, Sabine K. Maschke, C. L. A. Dewald, T. C. Meine, Hinrich B. M. Winther, M. M. Kirstein, Roman Kloeckner, Bernhard Christian Meyer, Frank K. Wacker, Jan B. Hinrichs

Abstract:

AIM: To evaluate the feasibility and potential value of two-dimensional (2D) parametric parenchymal blood flow (2D-PPBF) for the assessment of perfusion changes during transarterial chemoembolisation with drug-eluting beads (DEB-TACE) and to analyse correlations of 2D-PPBF parameters and tumour response. MATERIALS AND METHODS: Thirty-two patients (six women, 26 men, mean age: 67±8.9 years) with unresectable hepatocellular carcinoma (HCC) who underwent their first DEB-TACE were included in this study. To quantify perfusion changes using 2D-PPBF, the acquired digital subtraction angiography (DSA) series were post-processed. Ratios were calculated between the reference region of interest (ROI) and the wash-in rate (WIR), the arrival to peak (AP) and the area under the curve (AUC) of the generated time-density curves. Comparisons between pre- and post-embolisation data were made using the Wilcoxon signed-rank test. Tumour response was assessed at 3 months using the modified Response Evaluation Criteria in Solid Tumours (mRECIST) and correlated to changes of 2D-PPBF parameters. RESULTS: All 2D-PPBF parameters derived from the

Reference:

Two-dimensional parametric parenchymal blood flow in transarterial chemoembolisation for hepatocellular carcinoma: perfusion change quantification and tumour response prediction at 3 months post-intervention. (Lena S. Becker, Sabine K. Maschke, C. L. A. Dewald, T. C. Meine, Hinrich B. M. Winther, M. M. Kirstein, Roman Kloeckner, Bernhard Christian Meyer, Frank K. Wacker, Jan B. Hinrichs), In Clinical radiology, volume 76, 2021.

Bibtex Entry:

@article{becker_two-dimensional_2021,
	title = {Two-dimensional parametric parenchymal blood flow in transarterial chemoembolisation  for hepatocellular carcinoma: perfusion change quantification and tumour response  prediction at 3 months post-intervention.},
	volume = {76},
	copyright = {Copyright © 2020 The Royal College of Radiologists. Published by Elsevier Ltd. All  rights reserved.},
	issn = {1365-229X 0009-9260},
	doi = {10.1016/j.crad.2020.09.012},
	abstract = {AIM: To evaluate the feasibility and potential value of two-dimensional (2D)  parametric parenchymal blood flow (2D-PPBF) for the assessment of perfusion changes  during transarterial chemoembolisation with drug-eluting beads (DEB-TACE) and to  analyse correlations of 2D-PPBF parameters and tumour response. MATERIALS AND  METHODS: Thirty-two patients (six women, 26 men, mean age: 67±8.9 years) with  unresectable hepatocellular carcinoma (HCC) who underwent their first DEB-TACE were  included in this study. To quantify perfusion changes using 2D-PPBF, the acquired  digital subtraction angiography (DSA) series were post-processed. Ratios were  calculated between the reference region of interest (ROI) and the wash-in rate  (WIR), the arrival to peak (AP) and the area under the curve (AUC) of the generated  time-density curves. Comparisons between pre- and post-embolisation data were made  using the Wilcoxon signed-rank test. Tumour response was assessed at 3 months using  the modified Response Evaluation Criteria in Solid Tumours (mRECIST) and correlated  to changes of 2D-PPBF parameters. RESULTS: All 2D-PPBF parameters derived from the},
	language = {eng},
	number = {2},
	journal = {Clinical radiology},
	author = {Becker, Lena S. and Maschke, Sabine K. and Dewald, C. L. A. and Meine, T. C. and Winther, Hinrich B. M. and Kirstein, M. M. and Kloeckner, Roman and Meyer, Bernhard Christian and Wacker, Frank K. and Hinrichs, Jan B.},
	month = feb,
	year = {2021},
	pmid = {33028487},
	pages = {160.e27--160.e33}
}