by Robert Damm, Maciej Pech, Paola Cavalli, Florian Haag, Severin Gylstorff, Jazan Omari, Maximilian Thormann, Ricarda Seidensticker, Jens Ricke, Max Seidensticker, Borna Relja
Abstract:
Locoregional therapies, as imaging-guided tumor-directed procedures, are emerging treatment strategies in the management of primary and secondary liver malignancies such as e.g. colorectal cancer liver metastases. As one of those, irradiation-based interstitial high dose rate brachytherapy (iBT) of liver metastases bears a risk of developing focal radiation-induced liver injury (fRILI). Since little is known about biological factors involved in hepatic dysfunction after irradiation, the aim of this study was to identify factors, that may play a role in the underlying mechanism of fRILI, and that potentially may serve as biomarkers for post-therapeutic fRILI to improve specific management and treatment of patients.
Reference:
Correlation of chemokines and growth factors with radiation-induced liver injury after interstitial high dose rate (HDR) brachytherapy of liver metastases (Robert Damm, Maciej Pech, Paola Cavalli, Florian Haag, Severin Gylstorff, Jazan Omari, Maximilian Thormann, Ricarda Seidensticker, Jens Ricke, Max Seidensticker, Borna Relja), In Journal of Cancer Research and Clinical Oncology, volume 148, 2022.
Bibtex Entry:
@article{damm_correlation_2022,
title = {Correlation of chemokines and growth factors with radiation-induced liver injury after interstitial high dose rate ({HDR}) brachytherapy of liver metastases},
volume = {148},
issn = {1432-1335},
url = {https://doi.org/10.1007/s00432-022-04041-x},
doi = {10.1007/s00432-022-04041-x},
abstract = {Locoregional therapies, as imaging-guided tumor-directed procedures, are emerging treatment strategies in the management of primary and secondary liver malignancies such as e.g. colorectal cancer liver metastases. As one of those, irradiation-based interstitial high dose rate brachytherapy (iBT) of liver metastases bears a risk of developing focal radiation-induced liver injury (fRILI). Since little is known about biological factors involved in hepatic dysfunction after irradiation, the aim of this study was to identify factors, that may play a role in the underlying mechanism of fRILI, and that potentially may serve as biomarkers for post-therapeutic fRILI to improve specific management and treatment of patients.},
journal = {Journal of Cancer Research and Clinical Oncology},
author = {Damm, Robert and Pech, Maciej and Cavalli, Paola and Haag, Florian and Gylstorff, Severin and Omari, Jazan and Thormann, Maximilian and Seidensticker, Ricarda and Ricke, Jens and Seidensticker, Max and Relja, Borna},
month = may,
year = {2022},
pages = {2815--2826}
}