by Oliver S Grosser, Marcus Klutzny, Heiko Wissel, Dennis Kupitz, Michael Finger, Simone Schenke, Jan Wuestemann, Christoph H Lohmann, Christoph Hoeschen, Maciej Pech, Christian Staerke, Michael C Kreissl
Abstract:
SPECT-CT using radiolabeled phosphonates is considered a standard for assessing bone metabolism (e.g., in patients with osteoarthritis of knee joints). However, SPECT can be influenced by metal artifacts in CT caused by endoprostheses affecting attenuation correction. The current study examined the effects of metal artifacts in CT of a specific endoprosthesis design on quantitative hybrid SPECT-CT imaging. The implant was positioned inside a phantom homogenously filled with activity (955 MBq 99mTc). CT imaging was performed for different X-ray tube currents (I = 10, 40, 125 mA) and table pitches (p = 0.562 and 1.375). X-ray tube voltage (U = 120 kVp) and primary collimation (16 × 0.625 mm) were kept constant for all scans. The CT reconstruction was performed with five different reconstruction kernels (slice thickness, 1.25 mm and 3.75 mm, each 512 × 512 matrix). Effects from metal artifacts were analyzed for different CT scans and reconstruction protocols. ROI analysis of CT and SPECT data was performed for two slice positions/volumes representing the typical locations for target structures relative to the prosthesis (e.g., femur and tibia). A reference region (homogenous activity concentration without influence from metal artifacts) was analyzed for comparison.
Reference:
Quantitative imaging of bone remodeling in patients with a unicompartmental joint unloading knee implant (ATLAS Knee System)-effect of metal artifacts on a SPECT-CT-based quantification (Oliver S Grosser, Marcus Klutzny, Heiko Wissel, Dennis Kupitz, Michael Finger, Simone Schenke, Jan Wuestemann, Christoph H Lohmann, Christoph Hoeschen, Maciej Pech, Christian Staerke, Michael C Kreissl), In EJNMMI physics, volume 8, 2021.
Bibtex Entry:
@article{grosser_quantitative_2021,
	title = {Quantitative imaging of bone remodeling in patients with a unicompartmental joint unloading knee implant ({ATLAS} {Knee} {System})-effect of metal artifacts on a {SPECT}-{CT}-based quantification},
	volume = {8},
	issn = {2197-7364},
	url = {http://europepmc.org/abstract/MED/33595735},
	doi = {10.1186/s40658-021-00360-z},
	abstract = {SPECT-CT using radiolabeled phosphonates is considered a standard for assessing bone metabolism (e.g., in patients with osteoarthritis of knee joints). However, SPECT can be influenced by metal artifacts in CT caused by endoprostheses affecting attenuation correction. The current study examined the effects of metal artifacts in CT of a specific endoprosthesis design on quantitative hybrid SPECT-CT imaging. The implant was positioned inside a phantom homogenously filled with activity (955 MBq 99mTc). CT imaging was performed for different X-ray tube currents (I = 10, 40, 125 mA) and table pitches (p = 0.562 and 1.375). X-ray tube voltage (U = 120 kVp) and primary collimation (16 × 0.625 mm) were kept constant for all scans. The CT reconstruction was performed with five different reconstruction kernels (slice thickness, 1.25 mm and 3.75 mm, each 512 × 512 matrix). Effects from metal artifacts were analyzed for different CT scans and reconstruction protocols. ROI analysis of CT and SPECT data was performed for two slice positions/volumes representing the typical locations for target structures relative to the prosthesis (e.g., femur and tibia). A reference region (homogenous activity concentration without influence from metal artifacts) was analyzed for comparison.},
	language = {eng},
	number = {1},
	journal = {EJNMMI physics},
	author = {Grosser, Oliver S and Klutzny, Marcus and Wissel, Heiko and Kupitz, Dennis and Finger, Michael and Schenke, Simone and Wuestemann, Jan and Lohmann, Christoph H and Hoeschen, Christoph and Pech, Maciej and Staerke, Christian and Kreissl, Michael C},
	month = feb,
	year = {2021},
	pages = {15}
}