Prognostic Impact of Quality and Distribution of Adipose Tissue in Patients With Primary Central Nervous System Lymphoma.

Hinnerichs, Mattes; Ferraro, Vincenzo; Zeremski, Vanja; Mougiakakos, Dimitrios; Omari, Jazan; Pech, Maciej; Bär, Caroline; Wienke, Andreas; Saalfeld, Sylvia; Strobel, Alexandra; Surov, Alexey; Meyer, Hans Jonas; Wolleschak, Denise

doi:10.21873/invivo.13021

by Mattes Hinnerichs, Vincenzo Ferraro, Vanja Zeremski, Dimitrios Mougiakakos, Jazan Omari, Maciej Pech, Caroline Bär, Andreas Wienke, Sylvia Saalfeld, Alexandra Strobel, Alexey Surov, Hans Jonas Meyer, Denise Wolleschak

Abstract:

BACKGROUND/AIM: Body composition assessment has shown promising results as a prognostic biomarker as depicted by cross-sectional imaging of several tumor entities including lymphomas. The present study sought to elucidate the prognostic relevance of subcutaneous and visceral fat tissue (SAT and VAT) in patients with primary central nervous system lymphoma (PCNSL). PATIENTS AND METHODS: Overall, 74 patients (36 female patients, 46.7\%) with a mean age of 64.2±12.8 years (range=23-81 years) were identified in the database with sufficient clinical and imaging data and included into this retrospective study. Fat area assessment was performed on one axial slide on L3-height derived from staging computed tomography (CT) images. Subcutaneous, visceral, and intramuscular adipose tissues (SAT, VAT, IMAT) were estimated. Also, density of SAT, VAT, and IMAT were estimated. Finally, the ratio VAT/SAT (VSR) was calculated. Overall and progression-free survival (OS and PFS) were used as study end points. RESULTS: In the observation period, overall, 47 patients (63.5\%) died. Mean OS was 33.8±45.4 months and mean PFS was 26.6±42.7 months. The mean VAT value was 162±99.5 cm(2), the mean SAT was 202.4±103.3 cm(2), the mean VSR was 0.92±0.69. The hazard ratios (HRs) for overall survival were 0.87 for high VAT, 1.52 for SAT, and 0.73 for VSR in univariable analysis. For PFS it was 0.24 for VAT, 1.11 for SAT, and 1.07 for VSR. No values achieved statistical significance. Similar results were shown in Kaplan-Meier analysis for OS and PFS, respectively. CONCLUSION: Parameters of adipose tissue are not associated with OS and PFS in patients with PCNSL.

Reference:

Prognostic Impact of Quality and Distribution of Adipose Tissue in Patients With Primary Central Nervous System Lymphoma. (Mattes Hinnerichs, Vincenzo Ferraro, Vanja Zeremski, Dimitrios Mougiakakos, Jazan Omari, Maciej Pech, Caroline Bär, Andreas Wienke, Sylvia Saalfeld, Alexandra Strobel, Alexey Surov, Hans Jonas Meyer, Denise Wolleschak), In International Journal of Experimental and Clinical Pathophysiology and Drug Research - In Vivo, volume 36, 2022.

Bibtex Entry:

@article{hinnerichs_prognostic_2022,
	title = {Prognostic {Impact} of {Quality} and {Distribution} of {Adipose} {Tissue} in {Patients} {With}  {Primary} {Central} {Nervous} {System} {Lymphoma}.},
	volume = {36},
	copyright = {Copyright © 2022, International Institute of Anticancer Research (Dr. George J.  Delinasios), All rights reserved.},
	issn = {1791-7549 0258-851X 0258-851X},
	doi = {10.21873/invivo.13021},
	abstract = {BACKGROUND/AIM: Body composition assessment has shown promising results as a  prognostic biomarker as depicted by cross-sectional imaging of several tumor  entities including lymphomas. The present study sought to elucidate the  prognostic relevance of subcutaneous and visceral fat tissue (SAT and VAT) in  patients with primary central nervous system lymphoma (PCNSL). PATIENTS AND  METHODS: Overall, 74 patients (36 female patients, 46.7\%) with a mean age of  64.2±12.8 years (range=23-81 years) were identified in the database with  sufficient clinical and imaging data and included into this retrospective study.  Fat area assessment was performed on one axial slide on L3-height derived from  staging computed tomography (CT) images. Subcutaneous, visceral, and  intramuscular adipose tissues (SAT, VAT, IMAT) were estimated. Also, density of  SAT, VAT, and IMAT were estimated. Finally, the ratio VAT/SAT (VSR) was  calculated. Overall and progression-free survival (OS and PFS) were used as study  end points. RESULTS: In the observation period, overall, 47 patients (63.5\%)  died. Mean OS was 33.8±45.4 months and mean PFS was 26.6±42.7 months. The mean  VAT value was 162±99.5 cm(2), the mean SAT was 202.4±103.3 cm(2), the mean VSR  was 0.92±0.69. The hazard ratios (HRs) for overall survival were 0.87 for high  VAT, 1.52 for SAT, and 0.73 for VSR in univariable analysis. For PFS it was 0.24  for VAT, 1.11 for SAT, and 1.07 for VSR. No values achieved statistical  significance. Similar results were shown in Kaplan-Meier analysis for OS and PFS,  respectively. CONCLUSION: Parameters of adipose tissue are not associated with OS  and PFS in patients with PCNSL.},
	language = {eng},
	number = {6},
	journal = {International Journal of Experimental and Clinical Pathophysiology and Drug Research - In Vivo},
	author = {Hinnerichs, Mattes and Ferraro, Vincenzo and Zeremski, Vanja and Mougiakakos, Dimitrios and Omari, Jazan and Pech, Maciej and Bär, Caroline and Wienke, Andreas and Saalfeld, Sylvia and Strobel, Alexandra and Surov, Alexey and Meyer, Hans Jonas and Wolleschak, Denise},
	month = dec,
	year = {2022},
	pmid = {36309379},
	pmcid = {PMC9677753},
	keywords = {*Adipose Tissue/diagnostic imaging, *Intra-Abdominal Fat/diagnostic imaging/pathology, Aged, Body composition, Central Nervous System, cerebral lymphoma, CT, Female, Humans, Middle Aged, Prognosis, Retrospective Studies, Subcutaneous Fat/diagnostic imaging, visceral fat tissue},
	pages = {2828--2834}
}